A Model Approach: Mathematical modeling provides an increasingly clear picture of glucose and neural systems.

Mathematical modeling of physiological systems is a fundamental milestone of biomedical engineering. Models allow for the quantitative understanding of the intimate functions of a biological system, estimating parameters that are not accessible to direct measurement and performing in silico trials by simulating and tracking a physiological system in case its function has been deranged. Modeling has always been central in the Italian biomedical engineering community. Here, we review the progress in two areas: glucose and neurocomputational modeling with an emphasis on their clinical impact.