Title :
Compact Voltage and Current Stimulation Buffer for High-Density Microelectrode Arrays
Author :
Livi, P. ; Heer, F. ; Frey, U. ; Bakkum, D.J. ; Hierlemann, A.
Author_Institution :
Dept. of Biosystems Sci. & Eng., ETH Zurich, Basle, Switzerland
Abstract :
We report on a compact (0.02 mm2 ) buffer for both voltage and current stimulation of electrogenic cells on a complementary metal-oxide semiconductor microelectrode array. In voltage mode, the circuit is a high-current class-AB voltage follower, based on a local common-mode feedback (LCMFB) amplifier. In current mode, the circuit is a current conveyor of type II, using the same LCMFB amplifier with cascode stages to increase the gain. The circuit shows good linearity in the 0.5-3.5 V input range and has extensively been used for stimulation of neuronal cultures.
Keywords :
arrays; biomedical electrodes; cellular biophysics; microelectrodes; neurophysiology; complementary metal-oxide semiconductor microelectrode array; electrogenic cells; local common-mode feedback amplifier; microelectrode arrays; neuronal cultures; voltage 0.5 V to 3.5 V; CMOS technology; Current measurement; Microelectrodes; Microelectronic stimulation; Neurons; Voltage measurement; Class-AB; complementary metal–oxide semiconductor (CMOS)-based microelectrode array (MEA); current conveyor; extracellular recording and stimulation; local common-mode feedback (LCMFB); voltage and current buffer;
Journal_Title :
Biomedical Circuits and Systems, IEEE Transactions on
DOI :
10.1109/TBCAS.2010.2080676
