Title :
Magnetically guided micro-droplet using biological magnetic material for smart drug delivery system
Author :
Darong Oh ; Suwon Lee ; Jinhyuk Kim ; Hongsoo Choi ; Jongmo Seo ; Kyo-in Koo
Author_Institution :
Dept. of Electr. & Comput. Eng., Seoul Nat. Univ., Seoul, South Korea
Abstract :
Biodegradable polymer droplet containing magnetosome demonstrates active propulsion by magnetic field. Magnetosome is extracted from magnetotactic bacteria, AMB-1. Mixture of magnetosome and sodium alginate composes into droplet using the microfluidic device applied Plateau-Rayleigh instability principle. The magnetosome-contained droplet selects its route at the bifurcate microchannels by magnetic field. This shows tissue targeting potential of the proposed drug delivery system.
Keywords :
bifurcation; bioMEMS; biodegradable materials; biomagnetism; biomedical materials; biomembranes; drops; drug delivery systems; drugs; magnetic materials; magnetostatics; microchannel flow; microorganisms; mixtures; sodium compounds; AMB-1; Plateau-Rayleigh instability principle; biodegradable polymer droplet; biological magnetic material; magnetic field; magnetically guided microdroplet; magnetosome-sodium alginate mixture; magnetotactic bacteria; microchannel bifurcation; microfluidic device; smart drug delivery system; Drug delivery; Magnetic liquids; Magnetic resonance imaging; Magnetic separation; Magnetic tunneling; Microchannels;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
DOI :
10.1109/EMBC.2014.6943859
