Novel Protocols for P300-Based Brain–Computer Interfaces

The oddball protocol is often used in brain-computer interfaces (BCIs) to induce P300 ERPs, although, recently, some issues have been shown to detrimentally effect its performance. In this paper, we study a new periodic protocol and explore whether it can compete with the standard oddball protocol within the context of a BCI mouse. We found that the new protocol consistently and significantly outperforms the standard oddball protocol in relation to information transfer rates (33 bits/min for the former and 22 bits/min for the latter, measured at 90% accuracy) as well as P300 amplitudes. Furthermore, we performed a comparison of two periodic protocols with two less conventional oddball-like protocols that reveals the importance of the interactions between task and sequence in determining the success of a protocol.