DocumentCode :
1403560
Title :
Adaptive Real-Time Bioheat Transfer Models for Computer-Driven MR-Guided Laser Induced Thermal Therapy
Author :
Fuentes, David ; Feng, Yusheng ; Elliott, Andrew ; Shetty, Anil ; McNichols, Roger J. ; Oden, J. Tinsley ; Stafford, R.J.
Author_Institution :
Dept. of Imaging Phys., Univ. of Texas M.D. Anderson Cancer Center, Houston, TX, USA
Volume :
57
Issue :
5
fYear :
2010
fDate :
5/1/2010 12:00:00 AM
Firstpage :
1024
Lastpage :
1030
Abstract :
The treatment times of laser induced thermal therapies (LITT) guided by computational prediction are determined by the convergence behavior of partial differential equation (PDE)-constrained optimization problems. In this paper, we investigate the convergence behavior of a bioheat transfer constrained calibration problem to assess the feasibility of applying to real-time patient specific data. The calibration techniques utilize multiplanar thermal images obtained from the nondestructive in vivo heating of canine prostate. The calibration techniques attempt to adaptively recover the biothermal heterogeneities within the tissue on a patient-specific level and results in a formidable PDE constrained optimization problem to be solved in real time. A comprehensive calibration study is performed with both homogeneous and spatially heterogeneous biothermal model parameters with and without constitutive nonlinearities. Initial results presented here indicate that the calibration problems involving the inverse solution of thousands of model parameters can converge to a solution within three minutes and decrease the ||??||L 2 2 (0,T;L 2 (??)) norm of the difference between computational prediction and the measured temperature values to a patient-specific regime.
Keywords :
biomedical MRI; biothermics; convergence of numerical methods; heat transfer; laser applications in medicine; optimisation; partial differential equations; physiological models; radiation therapy; MR guided LITT; PDE constrained optimization problems; adaptive bioheat transfer models; bioheat transfer constrained calibration problem; biothermal heterogeneities; canine prostate; computer driven LITT; constitutive nonlinearities; heterogeneous biothermal model parameters; laser induced thermal therapy; multiplanar thermal images; optimization problem convergence behavior; partial differential equation; real time bioheat transfer models; Magnetic resonance (MR) temperature imaging; PDE-constrained optimization; real-time computing; Animals; Body Temperature; Computer Simulation; Computer Systems; Energy Transfer; Humans; Hyperthermia, Induced; Image Interpretation, Computer-Assisted; Laser Therapy, Low-Level; Magnetic Resonance Imaging; Models, Biological; Therapy, Computer-Assisted;
fLanguage :
English
Journal_Title :
Biomedical Engineering, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9294
Type :
jour
DOI :
10.1109/TBME.2009.2037733
Filename :
5406092
Link To Document :
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