Alveolar air Volatile Organic Compound extractor for clinical breath sampling

Author

de Silva, Geethanga ; Beyette, Fred R.

Author_Institution

Dept. of Electr. Eng. & Comput. Syst., Univ. of Cincinnati, Cincinnati, OH, USA

fYear

2014

fDate

26-30 Aug. 2014

Firstpage

5369

Lastpage

5372

Abstract

Alveolar air Volatile Organic Compound (VOC) extractor is a handheld breath-sampling device for clinical breath analysis. The device consists two main components: (1) An alveolar air separator, (2) A VOC extractor. The alveolar air separator splits exhaled air based on total exhaled air volume directing alveolar air towards the VOC extractor and dead space air to into an exhaust channel. The VOC extractor collects the VOCs from alveolar air into a modified Sold Phase Micro Extraction (SPME) filament. Feasibility of using the SPME filament to collect a quantifiable breath sample directly from exhaled breath is experimentally validated. Exhaled breath acetone is quantified using alveolar air VOC extractor and a GC/MS system.

Keywords

biomedical equipment; biomedical measurement; organic compounds; pneumodynamics; SPME filament; VOC extractor; alveolar air separator; alveolar air volatile organic compound extractor; clinical breath analysis; clinical breath sampling; dead space air; exhaled breath acetone; handheld breath-sampling device; sold phase micro extraction filament; total exhaled air volume; Actuators; Calibration; Containers; Needles; Particle separators; Standards; Volatile organic compounds;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1557-170X

Type

conf

DOI

10.1109/EMBC.2014.6944839

Filename

6944839