In situ calibration for quantitative ultrasonic imaging

We have considered the necessity of integral in situ calibration of acoustic properties for precision dimensional measurements and image rendering using ultrasound echo time-of-flight methods on living subjects. We have shown that by combining time-of-flight measurements over several paths with external measurements of transmitter and receiver locations generating those paths the relevant acoustic parameters and dimensional measurements can be extracted. It remains to be shown, theoretically and experimentally, that these methods can be successfully combined in a practical system that addresses natural geometries combining the impediments that we have herein addressed only separately