Title :
Mechanisms of Metabolic Fuel Selection: Modeling Human Metabolism and Body-Weight Change
Author_Institution :
Lab. of Biol. Modeling, Nat. Inst. of Diabetes & Digestive & Kidney Diseases, Bethesda, MD, USA
Abstract :
In this review, the current state of mathematical modeling of human metabolism was outlined together with the regulation of body weight and body composition. The following topics were discussed: energy balance models of body-weight change; mass-energy conversion factor and its relationship to body composition change; modelling steady-state changes of body weight; weight-loss kinetic modeling; metabolic fuel selection modelling beyond energy-balance models; fuel selection physiological mechanisms modelling; and, applications to wasting conditions such as cancer cachexia and future directions.
Keywords :
biochemistry; biological fluid dynamics; physiological models; body composition change; body-weight change; cancer cachexia; energy balance models; fuel selection physiological mechanism modelling; human metabolism; mass-energy conversion factor; metabolic fuel selection; metabolic fuel selection modelling; weight-loss kinetic modeling; Automotive engineering; Biochemistry; Combustion; Costs; Fuels; Humans; Mathematical model; Protein engineering; Thermodynamics; Vehicles; Body Weight; Computer Simulation; Eating; Energy Metabolism; Homeostasis; Humans; Models, Biological;
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
DOI :
10.1109/MEMB.2009.935465
