Title :
Towards a Healthy Human Model of Neural Disorders of Movement
Author :
Poizner, Howard ; Lancaster, Jeff ; Tunik, Eugene ; Narayana, Srinivas ; Franklin, C. ; Rogers, W. ; Xiaoyan Li ; Fox, Peter T. ; Robin, D.A.
Author_Institution :
Inst. for Neural Comput., Univ. of California-San Diego, La Jolla, CA, USA
Abstract :
A quantitative approach to virtual-lesion physiology is presented which integrates event-related fMRI, image-guided, repetitive, transcranial magnetic stimulation (irTMS), and simultaneous recording of 3-D movement kinematics. By linking motor neuroscience with clinical disorders of motor function, our method allows development of a healthy, human system model of disorders of skilled action.
Keywords :
biomechanics; biomedical MRI; brain; kinematics; neurophysiology; transcranial magnetic stimulation; 3D movement kinematics; TMS; clinical disorders; event-related fMRI; healthy human model; image-guided; linking motor neuroscience; motor function; neural disorders; simultaneous recording; transcranial magnetic stimulation; virtual-lesion physiology; Humans; Kinematics; Magnetic resonance imaging; Neuroimaging; Three dimensional displays; Apraxia; brain imaging; kinematics; motor control; Adult; Biomechanics; Cerebral Cortex; Data Interpretation, Statistical; Female; Gait Disorders, Neurologic; Hand; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Middle Aged; Models, Neurological; Motor Skills; Movement; Neuronavigation; Psychomotor Performance; Transcranial Magnetic Stimulation; User-Computer Interface;
Journal_Title :
Neural Systems and Rehabilitation Engineering, IEEE Transactions on
DOI :
10.1109/TNSRE.2012.2184769
