DocumentCode :
1430081
Title :
Real-Time Monitoring of Whole Blood Coagulation Using a Microfabricated Contour-Mode Film Bulk Acoustic Resonator
Author :
Xu, Wencheng ; Appel, Jennie ; Chae, Junseok
Author_Institution :
Sch. of Electr., Comput. & Energy Eng., Arizona State Univ., Tempe, AZ, USA
Volume :
21
Issue :
2
fYear :
2012
fDate :
4/1/2012 12:00:00 AM
Firstpage :
302
Lastpage :
307
Abstract :
We report a microelectromechanical systems contour-mode film bulk acoustic resonator (C-FBAR) to monitor in-vitro whole blood coagulation in real time. The C-FBAR has a suspended ring made of piezoelectric aluminum nitride excited in the radial-extensional mode. It operates at its resonant frequency of 150 MHz and possesses a quality factor of 77 in citrated human blood. The C-FBAR is characterized using aqueous glycerine solutions showing that it accurately measures the viscosity in the range of 1 to 10 centipoise. The C-FBAR, then, is used to monitor in-vitro blood coagulation processes in real time. Results show that its resonant frequency decreases as viscosity of the blood increases, during the fibrin generation process after the coagulation cascade. The coagulation time and the start/end of the fibrin generation are quantitatively determined. The C-FBAR has the potential to become a low-cost, portable, yet reliable tool for hemostasis diagnostics.
Keywords :
III-V semiconductors; Q-factor; acoustic resonators; aluminium compounds; bioMEMS; blood; coagulation; crystal resonators; microfabrication; patient diagnosis; patient monitoring; piezoelectric semiconductors; real-time systems; viscosity; wide band gap semiconductors; AlN; aqueous glycerine solutions; citrated human blood; fibrin generation process; frequency 150 MHz; hemostasis diagnostics; microelectromechanical systems; microfabricated contour-mode film bulk acoustic resonator; piezoelectric aluminum nitride; quality factor; radial-extensional mode; real-time monitoring; resonant frequency; viscosity; whole blood coagulation; Coagulation; Film bulk acoustic resonators; Monitoring; Real time systems; Resonant frequency; Viscosity; Acoustic resonators; blood coagulation; viscosity sensor;
fLanguage :
English
Journal_Title :
Microelectromechanical Systems, Journal of
Publisher :
ieee
ISSN :
1057-7157
Type :
jour
DOI :
10.1109/JMEMS.2011.2179011
Filename :
6138335
Link To Document :
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