Simulation of Ion Permeation in Biological Membranes

Author

Toghraee, Reza ; Lee, Kyu-Il ; Ravaioli, Umberto

Author_Institution

Univ. of Illinois at Urbana-Champaign, Urbana, IL, USA

Volume

12

Issue

2

fYear

2010

Firstpage

43

Lastpage

47

Abstract

As part of nature´s solution for regulating biological environments, ion channels are particularly interesting to device engineers seeking to understand how nanoscale molecular systems realize device-like functions, such as biosensing of organic analytes. By attaching molecular adaptors inside genetically engineered ion channels, it´s possible to further enhance this biosensor functionality.

Keywords

bioelectric phenomena; biomembrane transport; biomembranes; biosensors; nanobiotechnology; nonelectric sensing devices; permeability; biological membranes; biosensor functionality; device engineers; device-like functions; genetically engineered ion channels; ion channels; ion permeation; molecular adaptors; nanoscale molecular systems; organic analytes; Amino acids; Biological system modeling; Biomembranes; Cells (biology); Diseases; Electrostatics; Microorganisms; Nervous system; Protein engineering; Read only memory; α -Hemolysin; Ion channel; grid-focusing method; transport Monte Carlo simulation;

fLanguage

English

Journal_Title

Computing in Science & Engineering

Publisher

ieee

ISSN

1521-9615

Type

jour

DOI

10.1109/MCSE.2010.46

Filename

5432298