Title :
Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT)
Author :
Chen, Yu ; Yuan, Shuai ; Wierwille, Jeremiah ; Naphas, Renee ; Li, Qian ; Blackwell, Tiffany R. ; Winnard, Paul T., Jr. ; Raman, Venu ; Glunde, Kristine
Author_Institution :
Fischell Dept. of Bioeng., Univ. of Maryland, College Park, MD, USA
Abstract :
Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies. This paper briefly reviews current multimodal biophotonics imaging platforms in macroscopic, microscopic, and mesoscopic (or millimeter) scales. We also present a combined optical coherence tomography and line-scan fluorescence laminar optical tomography system for co-registered structural and molecular imaging with millimeter-scale imaging depth. Experimental results using a capillary phantom filled with the fluorescence dye Cy5.5 and a human breast cancer xenograft model are presented.
Keywords :
bio-optics; cancer; fluorescence; optical tomography; phantoms; Cy5.5; FLOT; OCT; biophotonics imaging technologies; capillary phantom; co-registered structural imaging; fluorescence dye; fluorescence laminar optical tomography; human breast cancer xenograft model; integrated optical coherence tomography; molecular imaging; multimodal imaging; Fluorescence laminar optical tomography (FLOT); multimodality imaging; optical coherence tomography (OCT);
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/JSTQE.2009.2037723
