DocumentCode :
15866
Title :
Measurement of Intravenously Administered 
Particle Amount in Mice Tissues Using Vibrating Sample Magnetometer
Author :
Kishimoto, Mikio ; Miyamoto, Ryoichi ; Oda, Tetsuya ; Ohara, Yuki ; Yanagihara, Hideto ; Ohkohchi, Nobuhiro ; Kita, Eiji
Author_Institution :
Inst. of Appl. Phys., Univ. of Tsukuba, Tsukuba, Japan
Volume :
13
Issue :
4
fYear :
2014
fDate :
Dec. 2014
Firstpage :
425
Lastpage :
430
Abstract :
Dispersions of platelet γ-Fe2O3 particles 30-50nm in size were intravenously administered to mice and the amount of particles accumulated in each tissue was obtained by magnetization measurement using a vibrating sample magnetometer. Background noise was greatly reduced by measuring dried tissues under a magnetic field of 500 Oe so that the effect of diamagnetism was slight. Remarkable particle accumulation was observed in the liver and spleen. Considerable particle accumulation was observed in the lung when a large quantity of γ-Fe2O3 particles was administered. There was no significant particle accumulation in the kidney and heart.
Keywords :
biological tissues; biomedical measurement; diamagnetism; iron compounds; liver; lung; magnetic particles; magnetic variables measurement; magnetometers; Fe2O3; background noise; diamagnetism; dried tissues; intravenous administered γ-Fe2O3 particle amount measurement; liver; lung; magnetic field; magnetization measurement; mice tissues; particle accumulation; platelet particle dispersions; spleen; vibrating sample magnetometer; Atmospheric measurements; Magnetic field measurement; Magnetic hysteresis; Magnetization; Mice; Particle measurements; Superconducting magnets;
fLanguage :
English
Journal_Title :
NanoBioscience, IEEE Transactions on
Publisher :
ieee
ISSN :
1536-1241
Type :
jour
DOI :
10.1109/TNB.2014.2337659
Filename :
6872794
Link To Document :
