DocumentCode
158676
Title
Mathematical study of the global dynamics of a concave gene expression model
Author
Belgacem, Ismail ; Gouze, Jean-Luc
Author_Institution
INRIA, BIOCORE Project-Team, Sophia Antipolis, France
fYear
2014
fDate
16-19 June 2014
Firstpage
1341
Lastpage
1346
Abstract
We describe in this paper the global dynamical behavior of a mathematical model of expression of polymerase in bacteria. This model is given by a differential system and algebraic equations. We use some tools from monotone systems theory with concavity of nonlinearities to obtain a global qualitative result: either the trivial equilibrium is globally stable, either there exists a unique positive equilibrium which is globally stable in the positive orthant. The same result holds for a class of qualitatively defined functions. Some generalizations of this result are given.
Keywords
cellular biophysics; differential algebraic equations; enzymes; genetics; microorganisms; molecular biophysics; algebraic equations; bacteria; concave gene expression model; differential system; global dynamical behavior; mathematical model; monotone system theory; nonlinearity concavity; polymerase expression; trivial equilibrium; unique positive equilibrium; Biological system modeling; Equations; Jacobian matrices; Mathematical model; Polymers; RNA; Stability analysis;
fLanguage
English
Publisher
ieee
Conference_Titel
Control and Automation (MED), 2014 22nd Mediterranean Conference of
Conference_Location
Palermo
Print_ISBN
978-1-4799-5900-6
Type
conf
DOI
10.1109/MED.2014.6961562
Filename
6961562
Link To Document