• DocumentCode
    158676
  • Title

    Mathematical study of the global dynamics of a concave gene expression model

  • Author

    Belgacem, Ismail ; Gouze, Jean-Luc

  • Author_Institution
    INRIA, BIOCORE Project-Team, Sophia Antipolis, France
  • fYear
    2014
  • fDate
    16-19 June 2014
  • Firstpage
    1341
  • Lastpage
    1346
  • Abstract
    We describe in this paper the global dynamical behavior of a mathematical model of expression of polymerase in bacteria. This model is given by a differential system and algebraic equations. We use some tools from monotone systems theory with concavity of nonlinearities to obtain a global qualitative result: either the trivial equilibrium is globally stable, either there exists a unique positive equilibrium which is globally stable in the positive orthant. The same result holds for a class of qualitatively defined functions. Some generalizations of this result are given.
  • Keywords
    cellular biophysics; differential algebraic equations; enzymes; genetics; microorganisms; molecular biophysics; algebraic equations; bacteria; concave gene expression model; differential system; global dynamical behavior; mathematical model; monotone system theory; nonlinearity concavity; polymerase expression; trivial equilibrium; unique positive equilibrium; Biological system modeling; Equations; Jacobian matrices; Mathematical model; Polymers; RNA; Stability analysis;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Control and Automation (MED), 2014 22nd Mediterranean Conference of
  • Conference_Location
    Palermo
  • Print_ISBN
    978-1-4799-5900-6
  • Type

    conf

  • DOI
    10.1109/MED.2014.6961562
  • Filename
    6961562