Endothelial dysfunction late after coronary angioplasty: a quantitative coronary angiographic study in patients without restenosis

Author

Vassanelli, C. ; Turri, M. ; Canali, G. ; Menegatti, G. ; Morando, G. ; Zanotto, G. ; Zanolla, L. ; Loschiavo, I. ; Zardini, P.

Author_Institution

Dept. of Cardiol., Verona Univ., Italy

fYear

1992

Firstpage

531

Lastpage

534

Abstract

Endothelial function after coronary angioplasty (PTCA) has been evaluated by quantitative coronary angiography in 18 patients with no evidence of significant restenosis at routine angiographic followup. Increasing doses of acetylcholine (Ach) were infused in the dilated coronary artery, followed by a 250μg bolus of nitroglycerin. Total PTCA segments examined were 21. The PTCA treated vessels showed abnormal response to Ach in all their segments. This vasoconstriction was more evident not only at the site of previous maximal stenosis but also in normal vascular sites stretched by the balloon. Vascular response to Ach suggests that endothelial function of neointima is impaired late after PTCA

Keywords

cardiology; diagnostic radiography; surgery; acetylcholine; balloon stretching; coronary angioplasty; dilated coronary artery; endothelial dysfunction; medical diagnostic imaging; neointima endothelial function; nitroglycerin; normal vascular sites; quantitative coronary angiography; restenosis; routine angiographic followup; vascular response; vasoconstriction; Angiography; Angioplasty; Arteries; Cardiac disease; Cardiology; Catheters; Coronary arteriosclerosis; Drugs; Performance analysis; Surgery;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 1992, Proceedings of

Conference_Location

Durham, NC

Print_ISBN

0-8186-3552-5

Type

conf

DOI

10.1109/CIC.1992.269530

Filename

269530