Title :
Stability of Cardiac Action Potential Duration under Periodic Pacing
Author :
Xiaodong, Han ; Hailang, Song ; Xiaomei, Wu ; Cuiwei, Yang ; Zuxiang, Fang
Author_Institution :
Dept. of Electron. Eng., Fudan Univ., Shanghai
Abstract :
Action potential duration (APD) alternans is believed to be a loss of stability and contributes much to the reentry arrhythmias. The purpose of this study is to analyze the stability conditions for one-dimension model and higher dimension model. These criterions are concluded by linear stability analysis in nonlinear dynamics. They should be useful for finding of cardiac control algorithms in low energy defibrillation and the designing of antiarrhythmic drug
Keywords :
bioelectric potentials; cardiology; physiological models; antiarrhythmic drug; cardiac action potential duration alternans; cardiac control algorithms; linear stability analysis; low energy defibrillation; nonlinear dynamics; periodic pacing; reentry arrhythmias; Algorithm design and analysis; Bifurcation; Cardiac tissue; Defibrillation; Drugs; Fibrillation; Frequency; Rhythm; Spirals; Stability analysis; APD alternans; Action potential duration (APD); arrhythmia; linear stability analysis; restitution property;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616361
