Voltage sensitive dye imaging system for awake and freely moving animals

Author

Park, Joon Hyuk ; Culurciello, Eugenio ; Kim, Dongsoo ; Verhagen, Justus Valentijn ; Gautam, Shree Hari ; Pieribone, Vincent

Author_Institution

Dept. of Electr. Eng., Yale Univ., New Haven, CT

fYear

2008

Firstpage

89

Lastpage

92

Abstract

A 32 times 32 pixel image sensor in bulk CMOS process for use in a custom voltage sensitive dye imaging system is presented. The system is to be mounted on awake and freely moving animals in order to measure brain activity. The image sensor is capable of on-chip temporal-differencing using a storage capacitor on-chip. Temporal-differencing is used to reduce the stress on the overall readout circuitry in order to meet size and power constraints of such a system. Each 75 mum times 75 mum pixel consists of a photodiode of 74 mum times 34 mum and a storage capacitor of 788 fF. The image sensor has a signal-to-noise ratio of 76 dB.

Keywords

CMOS image sensors; bioelectric phenomena; biomedical equipment; biomedical optical imaging; dyes; fluorescence; medical signal processing; neurophysiology; photodiodes; brain activity measurement; bulk CMOS process; capacitance 788 fF; image sensor; on chip storage capacitor; on chip temporal differencing; photodiode; picture size 32 pixel; readout circuitry; size 34 mum; size 74 mum; size 75 mum; voltage sensitive dye imaging system; Animals; Brain; CMOS process; Capacitors; Circuits; Image sensors; Image storage; Pixel; Stress; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference, 2008. BioCAS 2008. IEEE

Conference_Location

Baltimore, MD

Print_ISBN

978-1-4244-2878-6

Electronic_ISBN

978-1-4244-2879-3

Type

conf

DOI

10.1109/BIOCAS.2008.4696881

Filename

4696881