Hysteresis in CaMKII activity: A stochastic model

Author

Arun Anirudhan, V. ; Ranjith, G. ; Omkumar, R.V.

Author_Institution

Device Testing Lab., Sree Chitra Tirunal Inst. for Med. Sci. & Technol., Trivandrum, India

fYear

2014

fDate

24-27 Sept. 2014

Firstpage

440

Lastpage

444

Abstract

Calcium/calmodulin dependent protein kinase II (CaMKII) plays a crucial role in the induction of Long Term Potentiation. Several mathematical models have been developed to predict the activity levels of CaMKII in the physiological condition and its molecular switch properties. This paper attempts to study the hysteresis property of CaMKII using a stochastic model. It was observed that hysteresis exists under physiological conditions, but the width of the hysteresis band depends on the concentration of protein phosphatase 1 (PP1). The hysteresis band was maximum at low concentrations of PP1 and reduced with increasing concentrations of PP1. It was also observed that the number of phosphorylated subunits saturates beyond a threshold value of calcium signal.

Keywords

biochemistry; enzymes; molecular biophysics; physiological models; stochastic processes; CaMKII activity; PPI concentrations; calcium signal; calcium-calmodulin dependent protein kinase II; hysteresis band; hysteresis property; long term potentiation; mathematical models; molecular switch properties; phosphorylated subunits; physiological conditions; protein phosphatase 1 concentration; stochastic model; Abstracts; Biological system modeling; Calcium; Principal component analysis; Stochastic processes; CaMKII; bistability; hysteresis; stochastic model;

fLanguage

English

Publisher

ieee

Conference_Titel

Advances in Computing, Communications and Informatics (ICACCI, 2014 International Conference on

Conference_Location

New Delhi

Print_ISBN

978-1-4799-3078-4

Type

conf

DOI

10.1109/ICACCI.2014.6968567

Filename

6968567