Polyacrylic acid-derivatized superparamagnetic iron oxide nanoparticles for delivery of tissue plasminogen activator

Author

Chen, Jyh-Ping ; Yang, Pei-Chin ; Hwang, Hwei-Fang

Author_Institution

Dept. of Chem. & Mater. Eng., Chang Gung Univ., Taoyuan, Taiwan

fYear

2010

Firstpage

1391

Lastpage

1392

Abstract

Polyacrylic acid (PAA)-derivatized Fe₃O₄ magnetic nanoparticle (MNP) intended as a drug carrier were synthesized by two different approaches and studied for chemicophysical properties. PAA-MNP prepared by physical adsorption of PAA on pre-formed MNP showed better properties for covalent binding with a thrombolytic drug, recombinant tissue plasminogen activator (rtPA). The PAA-MNP-rtPA conjugate showed full retention of thrombolytic activity and is useful as a magnetically targeted drug carrier to improve clinical thrombolytic therapy.

Keywords

adsorption; biochemistry; biological tissues; biomedical materials; drugs; iron compounds; magnetic particles; nanobiotechnology; nanoparticles; superparamagnetism; Fe₃O₄; chemicophysical properties; clinical therapy; covalent binding; magnetic nanoparticle; physical adsorption; polyacrylic acid; recombinant tissue plasminogen activator; superparamagnetic iron oxide; thrombolytic drug; Design methodology; Drugs; Iron; Medical treatment; Morphology; Nanoparticles; Radiative recombination; SQUIDs; Spontaneous emission; Superconducting magnets;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanoelectronics Conference (INEC), 2010 3rd International

Conference_Location

Hong Kong

Print_ISBN

978-1-4244-3543-2

Electronic_ISBN

978-1-4244-3544-9

Type

conf

DOI

10.1109/INEC.2010.5424830

Filename

5424830