Preparation of a new nanosized As2O3/Mn0.5Zn0.5Fe2O4 thermosensitive magnetoliposome and its antitumor effect on MDA_MB_231 cells

Author

Wang, Li ; Wang, Ziyu ; Zhang, Dongsheng

Author_Institution

Jiangsu Province Key Lab. of Biomater., Southeast Univ., Nanjing, China

fYear

2010

Firstpage

1373

Lastpage

1374

Abstract

To explore the preparation method and characters of a new nanosized As₂O₃/Mn_0.5Zn_0.5Fe₂O₄ thermosensitive magnetoliposome and its antitumor effect on MDA_MB_231 cells. The nanosized As₂O₃/ Mn_0.5Zn_0.5Fe₂O₄ thermosensitive magnetoliposome was prepared by the method of rotatory film and high-pressure homogenization, and detected by TEM, SEM, EDS, atom fluorescence spectrophotometer spherical and DSC. The therapeutic effects of the nanosized thermosensitive magnetoliposomes combined hyperthermia on human MDA_MB_231 cells in vitro were evaluated by MTT assay and flow cytometry.

Keywords

X-ray chemical analysis; arsenic compounds; biomagnetism; biomedical materials; cellular biophysics; differential scanning calorimetry; ferrites; fluorescence; hyperthermia; magnetic particles; manganese compounds; nanobiotechnology; nanoparticles; scanning electron microscopy; transmission electron microscopy; tumours; zinc compounds; As₂O₃-Mn_0.5Zn_0.5Fe₂O₄; DSC; EDS; MDA_MB_231 cells; SEM; TEM; antitumor effect; atom fluorescence spectrophotometer; flow cytometry; high-pressure homogenization; hyperthermia; nanosized thermosensitive magnetoliposome; rotatory film; therapeutic effects; Drugs; Fluorescence; Heating; Humans; Hyperthermia; In vitro; Magnetic films; Nanoparticles; Scanning electron microscopy; Temperature;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanoelectronics Conference (INEC), 2010 3rd International

Conference_Location

Hong Kong

Print_ISBN

978-1-4244-3543-2

Electronic_ISBN

978-1-4244-3544-9

Type

conf

DOI

10.1109/INEC.2010.5424842

Filename

5424842