Title :
An ultrasensitive optofluidic nucleic acid biosensor
Author :
Measor, Philip ; Zhao, Yue ; Hawkins, Aaron R. ; Schmidt, Holger
Author_Institution :
Baskin Sch. of Eng., Univ. of California, Santa Cruz, CA, USA
Abstract :
Amplification-free nucleic acid testing using molecular beacon detection on an optofluidic chip is reported. A limit of detection at the single molecule detection level (10pM) and excellent specificity (single nucleotide mismatches) is observed.
Keywords :
bioMEMS; biosensors; chemical sensors; integrated optics; macromolecules; micro-optomechanical devices; microfluidics; microsensors; molecular biophysics; optical sensors; patient diagnosis; amplification-free nucleic acid testing; microsensors; molecular beacon detection; optofluidic chip; single molecule detection level; single nucleotide mismatches; ultrasensitive optofluidic nucleic acid biosensor; Biosensors; Diseases; Educational institutions; Fluorescence; Optical device fabrication; Optical sensors;
Conference_Titel :
Lasers and Electro-Optics (CLEO), 2012 Conference on
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-4673-1839-6
