Modeling of ventricular tissue and ECG reconstruction in acute and chronic ischemia

A realistic evolution of ischemia from coronary artery occlusion to myocardial infarction is investigated in order to identify the relationship between micro level changes and the surface ECG. Based on the available experimental results, a complete description of the pathological conditions was made, and the direct problem was stated algorithmically. Starting from a Luo-Rudy I cellular model a bi-dimensional structure was built in order to simulate the ventricular tissue. Chemical and electrical changes were induced gradually in order to simulate the evolution of the ischemic episode from acute phase to infarction. ECG reconstruction was performed during normal and acute ischemic conditions, infarction and after impairment when, despite the presence of a necrotic region, the chemical concentrations have returned to normal levels