• DocumentCode
    1706745
  • Title

    Protein complex identification by graph local clustering and use of Chou´s amphiphilic Pseudo amino-acid features

  • Author

    Nomani, Ashkan ; Mohammadbeigi, Mohsen ; Saleki, Amir

  • Author_Institution
    Biomed. Eng., Univ. of Isfahan, Isfahan, Iran
  • fYear
    2013
  • Firstpage
    247
  • Lastpage
    249
  • Abstract
    The intend of this paper is to introduce a new method for protein complex identification. Proteins share an important role by signaling cells. Proteins are three dimensional objects and any types of deformed proteins can cause severe disease, because their function is related to their shape and also the amino-acid sequence they have coded with. Technically speaking similar types of proteins tend to act by forming a group or a complex and if we can find a highly accurate way to identify the complexes we can find a group of proteins that are responsible for something. For this purpose different types of algorithms have proposed but most of them failed to achieve enough precision. Here we will use a new method which uses Chou Pseudo amino-acid as a set of features and we will get a good result even by using machine learning techniques that were supposed as not an effective tool in this field before.
  • Keywords
    biology computing; graph theory; learning (artificial intelligence); molecular biophysics; pattern clustering; proteins; Chou amphiphilic pseudoamino-acid features; amino-acid sequence; disease; graph local clustering; machine learning techniques; protein complex identification; Educational institutions; Eigenvalues and eigenfunctions; Kernel; Protein engineering; Proteins; Support vector machines; Complex; Identification; protein; yeast;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Biomedical Engineering (ICBME), 2013 20th Iranian Conference on
  • Conference_Location
    Tehran
  • Type

    conf

  • DOI
    10.1109/ICBME.2013.6782228
  • Filename
    6782228