Development and characterization of a nano-sized surfactant stabilized contrast agent for diagnostic ultrasound

Author

Dube, Neal K. ; Oeffinger, Brian E. ; Wheatley, Margaret A.

Author_Institution

Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA

fYear

2003

Firstpage

102

Lastpage

103

Abstract

ST68 is a surfactant based contrast agent being used to enhance diagnostic ultrasound imaging as well as develop a technique for targeting. The size of the ST68 nanobubbles is being reduced in order to facilitate passage through the tumor blood vessel pores. Different sonication times are being investigated in order to determine the smallest size of the nanobubbles. The contrast agent is characterized by dynamic light scattering and acoustic dose response to develop the maximum enhancement.

Keywords

biomedical ultrasonics; blood vessels; bubbles; light scattering; surfactants; tumours; ST68 nanobubbles; acoustic dose response; diagnostic ultrasound imaging; dynamic light scattering; maximum enhancement; nano-sized surfactant stabilized contrast agent; smallest size; sonication times; surfactant based contrast agent; targeting; tumor blood vessel pores; Acoustic imaging; Acoustic measurements; Biomedical engineering; Biomedical imaging; Blood vessels; Chemical engineering; Light scattering; Neoplasms; Ultrasonic imaging; Underwater acoustics;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of

Print_ISBN

0-7803-7767-2

Type

conf

DOI

10.1109/NEBC.2003.1216012

Filename

1216012