Peptide surface modification of PLA ultrasound contrast agent for targeting

Author

Leodore, L.M. ; Lathia, Justin D. ; Wheatley, Margaret A.

Author_Institution

Dept. of Bioscience & Biotechnol., Drexel Univ., Philadelphia, PA, USA

fYear

2003

Firstpage

193

Lastpage

194

Abstract

REDV and RGD peptide sequences were conjugated to hollow microspheres to develop targeted PLA ultrasound contrast agents that enhance imaging. The microspheres were coated with either RGD or REDV peptide sequences that target integrins active in angiogensis, α_vβ₃ and α_vβ₅. The microspheres were then shown to bind to human breast carcinoma cells in vitro within 5 minutes. The peptide modified microspheres makes them ideal candidates for targeted imaging.

Keywords

biomedical ultrasonics; cancer; cellular biophysics; mammography; organic compounds; tumours; 5 min; PLA ultrasound contrast agent; REDV peptide sequences; RGD peptide sequences; angiogenesis; hollow microspheres; human breast cancer; human breast carcinoma cell binding; human breast carcinoma cells; imaging enhancement; integrins; peptide modified microspheres; peptide sequences; peptide surface modification; targeted PLA ultrasound contrast agents; targeted imaging; targeting; tumor growth; Adhesives; Biological materials; Breast; Cells (biology); Humans; Peptides; Programmable logic arrays; Proteins; Sequences; Ultrasonic imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of

Print_ISBN

0-7803-7767-2

Type

conf

DOI

10.1109/NEBC.2003.1216059

Filename

1216059