Title :
Selenium nanoparticles used as drug delivery vehicles for tamoxifen
Author :
D´Antonio, Alyssa ; Webster, Thomas J.
Author_Institution :
Chem. Eng. Dept., Northeastern Univ., Boston, MA, USA
Abstract :
Breast cancer is not only the most common cancer in women but it is also the second most lethal. Tamoxifen (TAM) is a hydrophobic anticancer drug used for the early treatment of breast cancer. It is proposed here that Selenium (Se) nanoparticles can be used as a novel drug delivery vehicle to deliver TAM to cancer cells. By using Se-nanoparticles, issues involving proper distribution to the affected cancer cells can be improved upon. A more effective treatment method is desired so that the user could minimize the length of treatment while obtaining the same or even better results than current practices allow.
Keywords :
cancer; cellular biophysics; drug delivery systems; drugs; hydrophobicity; nanomedicine; nanoparticles; selenium; tumours; Se; breast cancer treatment; cancer cells; drug delivery vehicles; effective treatment method; hydrophobic anticancer drug; selenium nanoparticles; tamoxifen; treatment length; Biochemistry; Breast cancer; Drug delivery; Drugs; Nanoparticles; Breast cancer; Tamoxifen; drug delivery; selenium nanoparticles;
Conference_Titel :
Bioengineering Conference (NEBEC), 2014 40th Annual Northeast
Conference_Location :
Boston, MA
DOI :
10.1109/NEBEC.2014.6972766