Title :
Protein Local Tertiary Structure Prediction Using the Adaptively-Branching FGK-DF Model
Author :
Chen, Bing ; Hudson, Cody ; Crawford, Aaron ; MinWoo Kim
Author_Institution :
Dept. of Comput. Sci., Univ. of Central Arkansas, Conway, AR, USA
Abstract :
For the past twenty years, protein tertiary structure research has been given much attention. Unfortunately, each approach has significant shortcomings, such as necessary time, capital, or restrictions imposed by the method, limiting the resolution or novelty of produced tertiary structures. This work proposes the Adaptively-Branching Fuzzy Greedy K-means-Decision Forest (FGK-DF) model, which utilizes conserved sequential and structural motifs that transcend protein family boundaries, to predict the local tertiary structure of proteins with unknown structures.
Keywords :
biology computing; fuzzy set theory; greedy algorithms; molecular biophysics; proteins; adaptively-branching FGK-DF model; adaptively-branching fuzzy greedy k-means-decision forest model; conserved sequential motif; produced tertiary structures; protein family boundary; protein local tertiary structure prediction; protein tertiary structure research; structural motif; Adaptation models; Decision trees; Hidden Markov models; Predictive models; Proteins; Training; Vegetation; Adaptive Branch; Decision Forest; FGK Model;
Conference_Titel :
Machine Learning and Applications (ICMLA), 2013 12th International Conference on
Conference_Location :
Miami, FL
DOI :
10.1109/ICMLA.2013.77