Exploration of leukemia gene regulatory networks using a systems biology approach

Despite extensive studies in cytogenetic and mutations in leukemia cancer, new diagnoses were detected each year. This is due to multifactorial characteristic of hematopoietic disease and a lack of systematic-level information on genetic interaction and pathways between markers to understand the development and progression of leukemia. Thus, this study aims to sought a systems biology approach to infer gene regulatory networks of leukemia-related markers. Results demonstrated the effectiveness of a systems biology approach to simplify complex genetic interactions without losing important biological information of the genes. Key markers that inter-connected other leukemia-associated markers were identified.