DocumentCode :
1825854
Title :
Epileptogenic focus localization through connectivity analysis of the intracranial EEG: A retrospective study in 2 patients
Author :
van Mierlo, P. ; Carrette, E. ; Hallez, H. ; Vonck, K. ; Van Roost, D. ; Boon, P. ; Staelens, S.
Author_Institution :
Dept. of Electron. & Inf. Syst., Ghent Univ., Ghent, Belgium
fYear :
2011
fDate :
April 27 2011-May 1 2011
Firstpage :
655
Lastpage :
658
Abstract :
Some patients with refractory epilepsy can benefit from surgical removal of the brain region responsible for causing the epileptic seizures, i.e. the epileptogenic focus. In several cases the patient is admitted for Invasive Video Electroencephalography Monitoring (IVEM) to delineate the ictal onset zone based on intracranial electroencephalographic (IEEG) signals. However, in clinical practice this delineation is based on a visual identification strategy out of the IEEG signals. The purpose of this study is to identify the epileptogenic focus based on the concept of functional brain connectivity. The full frequency Adapted Directed Transfer Function (ffADTF) values were calculated for each seizure of the 2 investigated patients. The mean out-degree, i.e. the sum of outgoing connections, over all seizures for each patient was calculated out of the ffADTF-values. The epileptogenic focus was identified based on the mean out-degree. The localization of the hypothesized epileptogenic focus in the 2 patients was concordant with post-operative findings. We showed that connectivity patterns derived out of the ffADTF analysis can provide useful information about seizure propagation and may improve the accuracy of the presurgical evaluation in patients affected by refractory epilepsy.
Keywords :
electroencephalography; medical disorders; medical signal processing; patient monitoring; brain; connectivity analysis; epileptic seizures; epileptogenic focus localization; full frequency adapted directed transfer function; functional brain connectivity; ictal onset zone; intracranial EEG; invasive video electroencephalography monitoring; refractory epilepsy; surgical removal; visual identification strategy; Adaptation model; Brain; Electrodes; Electroencephalography; Epilepsy; Monitoring; Transfer functions;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Neural Engineering (NER), 2011 5th International IEEE/EMBS Conference on
Conference_Location :
Cancun
ISSN :
1948-3546
Print_ISBN :
978-1-4244-4140-2
Type :
conf
DOI :
10.1109/NER.2011.5910633
Filename :
5910633
Link To Document :
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