DocumentCode :
1827402
Title :
Effective voigt model estimation using multiple random starting values and parameter bounds settings for in vivo hepatic 1H magnetic resonance spectroscopic data
Author :
Ratiney, H. ; Bucur, A. ; Sdika, M. ; Beuf, O. ; Pilleul, F. ; Cavassila, S.
Author_Institution :
CREATIS-LRMN, Univ. Lyon, Villeurbanne
fYear :
2008
fDate :
14-17 May 2008
Firstpage :
1529
Lastpage :
1532
Abstract :
In vivo hepatic 1H lineshapes modeled by the complex Voigt function are desirable to reduce systematic error and obtain accurate fits. However, the optimization procedure becomes challenging when the peak resonances overlap and the proportion of Gaussian to Lorentzian dampings is a priori unknown. In this context, nonlinear least-squares algorithms generally invoked in Magnetic Resonance Spectroscopy quantification are highly sensitive to the starting values and parameter bounds. To alleviate this sensitivity, multiple random starting values and parameter bounds settings are used to generate candidate solutions. The "best fit" fulfilling requirements on the cost function and damping factor final values is then selected among them. Monte Carlo studies and an in vivo hepatic 1H signal quantification demonstrated the relevance of the proposed strategy.
Keywords :
Monte Carlo methods; NMR line breadth; biomedical MRI; least squares approximations; liver; minimisation; physiological models; Monte Carlo method; Voigt lineshapes; Voigt model estimation; damping factor; human liver signals; in vivo hepatic 1H magnetic resonance spectroscopy; minimization algorithm; multiple random starting values; nonlinear least-squares algorithms; optimization; parameter bounds settings; Damping; Displays; Humans; In vivo; Magnetic resonance; Mathematical model; Minimization methods; Robustness; Spectroscopy; Time domain analysis; Magnetic Resonance Spectroscopy; Voigt Lineshape; model parameter bounds; optimization; starting values;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2008. ISBI 2008. 5th IEEE International Symposium on
Conference_Location :
Paris
Print_ISBN :
978-1-4244-2002-5
Electronic_ISBN :
978-1-4244-2003-2
Type :
conf
DOI :
10.1109/ISBI.2008.4541300
Filename :
4541300
Link To Document :
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