Title :
A New Non-invasive Method for Measuring Blood Glucose Using Instantaneous Differential Near Infrared Spectrophotometry
Author :
Yamakoshi, Y. ; Ogawa, Michiko ; Yamakoshi, T. ; Satoh, M. ; Nogawa, M. ; Tanaka, Shoji ; Tamura, T. ; Rolfe, P. ; Yamakoshi, K.
Author_Institution :
TYT Inst. of Technol. Corp., Kanazawa
Abstract :
We describe further development of a novel method for non-invasive measurement of blood glucose concentration (BGL), named Pulse Glucometry, based on differential near infrared spectrophotometry. Sequential temporal differences of infrared transmittance spectra from the radiation intensity (Ilambda) emerging from a fingertip containing an arterial pulse component (DeltaIlambda) are analysed. To perform the measurements we developed a new high-speed spectrophotometer, covering the wavelength range from 900 to 1700 nm, scanning at a maximum spectral rate of 1800 spectra/s, with a minimum exposure time of 20 mus. Spectra related only to the pulsatile blood component are derived, thus minimising influences of basal components such as resting blood volume, skin, muscle and bone. We have now improved the performance of the spectrophotometer and in the present paper we describe new in vivo measurements carried out in 23 healthy volunteers undergoing glucose tolerance tests. Blood samples were collected from the cephalic vein simultaneously with radiation intensity measurements in the fingertip every 10 min before and after oral administration of glucose solution for 120 min. BGL values were then predicted using a PLS calibration model and compared with blood values determined by colorimetric assay. The precision and accuracy of the non-invasive determinations are encouraging.
Keywords :
bio-optics; biomedical measurement; blood; patient diagnosis; spectrophotometry; sugar; BGL; PLS calibration model; cephalic vein blood samples; fingertip infrared transmittance spectra; glucose tolerance test; high speed spectrophotometer; instantaneous differential NIR spectrophotometry; noninvasive blood glucose measurment; pulsatile blood component; pulse glucometry; time 20 mus; wavelength 900 nm to 1700 nm; Blood; Bones; Infrared spectra; Muscles; Performance evaluation; Pulse measurements; Skin; Sugar; Time measurement; Wavelength measurement; Blood Chemical Analysis; Blood Glucose; Feasibility Studies; Fiber Optic Technology; Humans; Oximetry; Pilot Projects; Reproducibility of Results; Sensitivity and Specificity; Spectroscopy, Near-Infrared;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4352951