Title :
Wnt Signaling Pathway-Based Analysis of Variance on Different Subtypes of Breast
Author :
Zhao-qi Wang ; Ping Chen ; Lin Hua ; Ping Zhou
Author_Institution :
Sch. of Basic Med. Sci., Capital Med. Univ., Beijing, China
Abstract :
We verified the variance of Wnt signaling pathway among different subtypes of breast cancer. Gene expression profile data of breast cancer (series number GSE19536) were obtained from Gene Expression Omnibus (GEO) database of National Center for Biotechnology Information (NCBI). Breast cancer samples were served as study materials. Gene expression data of Wnt signaling pathways were analyzed by variance analysis. We found 31 genes in Wnt-signaling pathway with significant differences among the applied methods. The results confirm that Wnt signaling pathway express distinctly in different subtypes of breast cancer.
Keywords :
bioinformatics; biotechnology; cancer; National Center for Biotechnology Information; Wnt signaling pathway-based analysis; breast cancer; gene expression omnibus database; gene expression profile data; variance analysis; Analysis of variance; Breast cancer; Educational institutions; Gene expression; Materials; Tumors; analysis of variance; breast cancer; wnt signaling pathway;
Conference_Titel :
Computational and Information Sciences (ICCIS), 2013 Fifth International Conference on
Conference_Location :
Shiyang
DOI :
10.1109/ICCIS.2013.71
