A CMOS-based sensor array for in-vitro neural tissue interfacing with 4225 recording sites and 1024 stimulation sites

Author

Bertotti, G. ; Velychko, D. ; Dodel, N. ; Keil, S. ; Wolansky, D. ; Tillak, B. ; Schreiter, M. ; Grall, A. ; Jesinger, P. ; Rohler, S. ; Eickenscheidt, M. ; Stett, A. ; Moller, A. ; Boven, K.-H. ; Zeck, G. ; Thewes, R.

Author_Institution

Fac. of EECS, Sensor & Actuator Syst., Tech. Univ. Berlin, Berlin, Germany

fYear

2014

fDate

22-24 Oct. 2014

Firstpage

304

Lastpage

307

Abstract

A CMOS-based microelectrode array (MEA) with 4225 recording sites and 1024 stimulation sites and a related data acquisition system are presented. The chip provides high spatiotemporal resolution on an active area of 1 mm × 1 mm or 2 mm × 2 mm, respectively, and allows in-vitro neural tissue interfacing experiments with full imaging capability. The entire chip surface is covered by a thin high-k dielectric layer so that electric coupling between biological tissue and solid-state chip is purely capacitive. Biological experiments reveal proper functionality of the system.

Keywords

CMOS integrated circuits; bioelectric phenomena; biological tissues; data acquisition; lab-on-a-chip; microelectrodes; microsensors; spatiotemporal phenomena; CMOS-based microelectrode array; CMOS-based sensor array; data acquisition system; electric coupling; high spatiotemporal resolution; in-vitro neural tissue interfacing; solid-state chip; thin high-k dielectric layer; Arrays; CMOS integrated circuits; Electrodes; Noise; Semiconductor device measurement; Sensors; Transistors;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference (BioCAS), 2014 IEEE

Conference_Location

Lausanne

Type

conf

DOI

10.1109/BioCAS.2014.6981723

Filename

6981723