Title :
Building reconfigurable circuitry in a biochemical world
Author :
Chiang, H.-J.K. ; Jiang, J.-H.R. ; Fagesy, F.
Author_Institution :
Grad. Inst. of Electron. Eng., Nat. Taiwan Univ., Taipei, Taiwan
Abstract :
Realizing complex systems within a biochemical environment is a common pursuit in synthetic biology, an emerging technology with promising potential in biomedicine and other applications. Such systems achieve certain computation through properly designed biochemical reactions. Despite fruitful progress being made, most existing reaction designs have fixed target functionality. Their lack of reconfigurability can be disadvantageous, especially when a system has to adapt to a varying biochemical environment. In this paper, we propose an analog approach to economically construct a reconfigurable logic circuit similar to a silicon based field programmable gate array (FPGA). The effective “logic” and “interconnect” of the circuit can be dynamically reconfigured by controlling the concentrations of certain knob species. We study a potential biomedical application of our reconfigurable circuitry to disease diagnosis and therapy at a molecular level.
Keywords :
biochemistry; complex networks; diseases; field programmable gate arrays; interconnections; logic circuits; logic gates; molecular biophysics; patient diagnosis; patient treatment; silicon; FPGA; analog approach; biochemical environment; biochemical reactions; biochemical world; biomedical application; biomedicine; complex systems; disease diagnosis; disease therapy; effective circuit interconnect; effective circuit logic; fixed target functionality; knob species concentrations; molecular level; reaction designs; reconfigurability; reconfigurable circuitry; reconfigurable logic circuit; silicon based field programmable gate array; synthetic biology; Buildings; DNA; Diseases; Equations; Integrated circuit interconnections; Logic gates; Variable speed drives;
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2014 IEEE
Conference_Location :
Lausanne
DOI :
10.1109/BioCAS.2014.6981787