DocumentCode :
1854023
Title :
Multiscale regularity analysis of the Heart Rate Variability: stratification of cardiac death risk
Author :
Valencia, J.F. ; Vallverdu, M. ; Cygankiewicz, I. ; Voss, A. ; Vazquez, R. ; de Luna, A.B. ; Caminal, P.
Author_Institution :
Tech. Univ. of Catalonia, Barcelona
fYear :
2007
fDate :
22-26 Aug. 2007
Firstpage :
5946
Lastpage :
5949
Abstract :
Subjects with ischemic dilated cardiomiopathy tend to suffer episodes of sudden cardiac death, thus risk stratification is essential to establish an adequate therapy for the patients. In this work, a new methodology was proposed for the study of the heart rate variability by using a multiscale analysis based on the concept of entropy rates, for improving risk prediction in cardiac patients. Symbolic dynamics were applied to RR time series and sets of words in several scales were constructed. The multiscale regularity analysis was proposed by comparing the entropies, calculated using Shannon and Renyi definitions, of the series of words in different scales. The study considered the selection of the best parameters for the length of the words (I) and the order of the entropies (q). Statistical analysis with repeated measures and discriminant analysis revealed statistically significant differences (p-value<0.05) and a high percentage of well classified subjects in their different risk groups, with sensitivity, specificity and positive predictive values of 100%.
Keywords :
electrocardiography; entropy; medical signal processing; statistical analysis; time series; RR time series; Renyi entropy; Shannon entropy; cardiac death risk; discriminant analysis; entropy rates; heart rate variability; ischemic dilated cardiomiopathy; multiscale regularity analysis; risk stratification; statistical analysis; Analysis of variance; Autonomic nervous system; Cardiac disease; Cardiology; Entropy; Heart rate variability; Probability distribution; Risk analysis; Sleep; Statistical analysis; Arrhythmias, Cardiac; Cardiomyopathy, Dilated; Comorbidity; Death, Sudden, Cardiac; Diagnosis, Computer-Assisted; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Male; Proportional Hazards Models; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Spain; Survival Analysis; Survival Rate;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
ISSN :
1557-170X
Print_ISBN :
978-1-4244-0787-3
Type :
conf
DOI :
10.1109/IEMBS.2007.4353702
Filename :
4353702
Link To Document :
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