Title :
Simulation of closed-loop rate-adaptive pacing with a numerical heart and circulation model
Author :
Schaldach, Max ; Urbaszek, Albrecht ; Hutten, Helmut
Author_Institution :
Zentralinst. fur Biomed. Tech., Erlangen-Nurnberg Univ., Germany
Abstract :
A numerical model of the human cardiovascular system was developed to study the chronotropic and inotropic responses of the heart as well as peripheral adaptation to changing metabolic demands. Autonomic nervous system (ANS) control covers all three levels of the model: circulation, heart mechanics and myocardial cell. The purpose of the simulations is to investigate the control aspects of rate responsive pacing and to develop and test algorithms for rate adaptation based on cardiac control signals, of which unipolar intracardiac impedance measurements are of special interest
Keywords :
biocontrol; cardiology; closed loop systems; haemodynamics; neurophysiology; pacemakers; physiological models; algorithms; autonomic nervous system control; cardiac control signals; changing metabolic demands; chronotropic responses; closed-loop rate-adaptive pacing simulation; heart mechanics; inotropic responses; myocardial cell; numerical heart/circulation model; peripheral adaptation; rate responsive pacing; unipolar intracardiac impedance measurements; Autonomic nervous system; Cardiovascular system; Circulatory system; Control system synthesis; Geometry; Heart; Humans; Impedance measurement; Myocardium; Numerical models; Pacemakers; Process control; Testing;
Conference_Titel :
Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2050-6
DOI :
10.1109/IEMBS.1994.412109
