Title :
Microfluidic high-resolution NMR chip for biological fluids
Author :
Gardeniers, J.G.E. ; Bart, J. ; Kolkman, A.J. ; de Vries, A.-J. ; Janssen, J.W.G. ; van Bentum, P.J.M. ; Ampt, K.A.M. ; Wijmenga, S.S. ; Kentgens, A.P.M.
Author_Institution :
MESA+ Inst. for Nanotechnol., Univ. of Twente, Enschede, Netherlands
Abstract :
This contribution describes a silicon-based microfluidic chip with an integrated RF stripline for NMR detection, with high spectral resolution (ca. 1 Hz at 600 MHz proton resonance) and high sensitivity (ca. 1.2 mM) for mass-limited (600 nL) biological samples, with a particular focus on human cerebrospinal fluid samples.
Keywords :
bioMEMS; biological fluid dynamics; biomedical MRI; microfluidics; silicon; NMR detection; Si; biological fluids; biological samples; frequency 600 MHz; human cerebrospinal fluid samples; integrated RF stripline; silicon-based microfluidic chip; Coils; Information analysis; Magnetic fields; Magnetic liquids; Microfluidics; Nuclear magnetic resonance; Radio frequency; Solenoids; Stripline; Strips; Microfluidics; NMR; biological fluids; mass-limited samples;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International
Conference_Location :
Denver, CO
Print_ISBN :
978-1-4244-4190-7
Electronic_ISBN :
978-1-4244-4193-8
DOI :
10.1109/SENSOR.2009.5285775
