Magnetic particle dosing, release and separation in a microfluidic chip with magnetic actuation

Author

Afshar, R. ; Lehnert, T. ; Moser, Y. ; Gijs, M.A.M.

Author_Institution

Lab. of Microsyst., Ecole Polytech. Fed. de Lausanne, Lausanne, Switzerland

fYear

2009

fDate

21-25 June 2009

Firstpage

1238

Lastpage

1241

Abstract

Separation of functionalized magnetic particles or magnetically-labeled entities is an important tool in the field of bioanalysis. We present a novel integrated microfluidic magnetic bead separation device. On-chip manipulation of superparamagnetic beads is performed in a microfluidic channel under the influence of a highly focused magnetic field. Integrated magnetic microtips are used for retaining a defined amount of magnetic particles in a localized plug. This plug is released in a well-controlled way for subsequent particle separation with respect to their size and magnetic volume.

Keywords

electromagnetic actuators; magnetic particles; microfluidics; bioanalysis; functionalized magnetic particles; magnetic actuation; magnetic bead separation device; magnetic particle dosing; magnetically-labeled entities; microfluidic channel; microfluidic chip; superparamagnetic beads; Coils; Magnetic fields; Magnetic particles; Magnetic separation; Microchannel; Microfluidics; Micromagnetics; Plugs; Proteins; Soft magnetic materials; Magnetic separation; magnetophoresis; microfluidics;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International

Conference_Location

Denver, CO

Print_ISBN

978-1-4244-4190-7

Electronic_ISBN

978-1-4244-4193-8

Type

conf

DOI

10.1109/SENSOR.2009.5285882

Filename

5285882