Title :
An implantable 5mW/channel dual-wavelength optogenetic stimulator for therapeutic neuromodulation research
Author :
Paralikar, Kunal ; Peng Cong ; Santa, Wes ; Dinsmoor, David ; Hocken, Bob ; Munns, G. ; Giftakis, J. ; Denison, Tim
Author_Institution :
Medtronic Technol., Minneapolis, MN, USA
Abstract :
This paper describes an implantable system prototype capable of delivering optical intensities and modulation patterns suitable to therapeutically modulate neural networks. It leverages the emerging "optogenetic" interface paradigm for exciting or inhibiting neural activity with the advantages of genetically targeted stimulation and enhanced MRI/EMI compatibility.
Keywords :
bioelectric phenomena; biomedical MRI; biomolecular effects of radiation; cellular biophysics; electromagnetic interference; neural nets; neurophysiology; patient treatment; prosthetics; proteins; MRI-EMI compatibility; genetically targeted stimulation; implantable dual wavelength optogenetic stimulator; neural network modulation; optical intensity; optical modulation patterns; optogenetic interface paradigm; therapeutic neuromodulation; Electrodes; Light emitting diodes; Medical treatment; Optical scattering; Optical sensors; Optical transmitters; Photonic integrated circuits; Power system management; Stimulated emission; Telemetry;
Conference_Titel :
Solid-State Circuits Conference Digest of Technical Papers (ISSCC), 2010 IEEE International
Conference_Location :
San Francisco, CA
Print_ISBN :
978-1-4244-6033-5
DOI :
10.1109/ISSCC.2010.5433938
