Bio-thermochemical sensor with liposome immobilized intact for protein detection using their interaction and membrane dynamics

We have developed a new scheme of bio-thermochemical microbolometer with a small amount of droplet solution consisting from liposome and biochemical target molecules. And newly detected bio-thermochemical reaction between 2-dipalmitoyl-sn-glycero-3-phosphocholline) liposome immobilized intact and protein of lysozyme (enzyme) in a droplet on a Pt thin film microbolometer, where they are dissolved with concentration of 30 mM and 30 muM, respectively, a droplet with volume of about 65 nL is immobilized on the surface of Pt film bolometer. This paper reports our first experimental results showing interaction between the DPPC liposome and lysozyme by the new scheme of bio-thermochemical sensor.