Characterization of probabilistic signaling networks through signal propagation

A large volume of research has been done to uncover different characteristics of biological network, such as large-scale organization, node centrality and network robustness. Nevertheless, the vast majority of research done in this area assume that biological networks have deterministic topologies. Biological interactions are however probabilistic events that may or may not appear at different cells or even in the same cell at different times. In this paper, we present results for characterizing H. sapiens probabilistic signaling networks using signal reachability, with respect to (i) centrality of nodes, (ii) stability of the network, and (iii) important network functions.