DocumentCode
1963102
Title
Real-time label-free detection of DNA synthesis by FBAR-based mass sensing
Author
Lin, Anderson ; Sahin, Furkan E. ; Chen, Shih-Jui ; Pham, Phuong ; Kim, Eun Sok
Author_Institution
Dept. of Electr. Eng.-Electrophys., Univ. of Southern, CA, USA
fYear
2010
fDate
11-14 Oct. 2010
Firstpage
1286
Lastpage
1289
Abstract
This paper reports a real-time detection of DNA polymerase reaction through mass sensing with film bulk acoustic resonator (FBAR) coated with self-assembled DNA sequences. This label-free, real-time detection of DNA synthesis can potentially lead to detection of single nucleotide addition for DNA sequencing application, which can be developed into a low-cost, third-generation DNA sequencing system capable of reading thousands of nucleotides in a single run.
Keywords
DNA; acoustic resonators; biomedical ultrasonics; bulk acoustic wave devices; self-assembly; DNA polymerase reaction; DNA synthesis; FBAR-based mass sensing; film bulk acoustic resonator; real-time label-free detection; self-assembled DNA sequences; single nucleotide addition; DNA; Electrodes; Film bulk acoustic resonators; Frequency measurement; Gold; Polymers; Resonant frequency;
fLanguage
English
Publisher
ieee
Conference_Titel
Ultrasonics Symposium (IUS), 2010 IEEE
Conference_Location
San Diego, CA
ISSN
1948-5719
Print_ISBN
978-1-4577-0382-9
Type
conf
DOI
10.1109/ULTSYM.2010.5935968
Filename
5935968
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