SERS study of tetrodotoxin (TTX) by using silver nanoparticle arrays

Author

Lin, Wen-Chi ; Jen, Hsiao-Chin ; Chen, Chang-Long ; Hwang, Deng-Fwu ; Chang, Railing ; Hwang, Jih-Shang ; Chiang, Hai-Pang

Author_Institution

Inst. of Optoelectron. Sci., Nat. Taiwan Ocean Univ., Keelung, Taiwan

fYear

2009

fDate

30-3 Aug. 2009

Firstpage

1

Lastpage

2

Abstract

The optical properties of tetrodotoxin (TTX), a scarce toxin with anesthetic properties, were studied using nanoparticle arrays-assisted surface-enhanced Raman scattering (SERS). The nanoparticles arrays were fabricated using nanosphere lithography and a metallic lift-off process to control the particle size, shape, and spacing in the arrays. In the SERS experiment, we were able to measure the Raman spectrum with a TTX concentration as less as 0.9 ng/mL. This sensitivity is comparable to that from high performance liquid chromatography.

Keywords

nanoparticles; spectrochemical analysis; surface enhanced Raman scattering; toxicology; Ag; Raman spectra; TTX; anesthetic property; nanoparticle arrays; optical property; surface enhanced Raman scattering; tetrodotoxin SERS study; Anesthetic drugs; Lithography; Nanoparticles; Optical arrays; Optical scattering; Optical sensors; Raman scattering; Shape control; Silver; Size control; Ag nanoparticle arrays; Density functional theory (DFT); Nanosphere lithography (NSL); Surface enhaced Raman scattering (SERS); Tetrodotoxin (TTX);

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers & Electro Optics & The Pacific Rim Conference on Lasers and Electro-Optics, 2009. CLEO/PACIFIC RIM '09. Conference on

Conference_Location

Shanghai

Print_ISBN

978-1-4244-3829-7

Electronic_ISBN

978-1-4244-3830-3

Type

conf

DOI

10.1109/CLEOPR.2009.5292414

Filename

5292414