Title :
Neuroplastic alterations accompanying long-term depression in the anesthetized rat hippocampus
Author :
Blaise, J. Harry ; Bronzino, J.D.
Author_Institution :
Dept. of Electr. & Syst. Eng., Connecticut Univ., Storrs, CT, USA
Abstract :
The major goals of this study were to: (1) assess whether low-frequency stimulation (LFS) is effective at inducing long-term depression (LTD) of the perforant path/dentate gyrus synapse in the anesthetized adult rat hippocampus, and (2) determine the frequency at which the shift from LTD to LTP occurs. Measures of homosynaptic LTD were recorded in the dentate gyrus during experiments conducted on anesthetized adult rats, Our results indicate that stimulation frequencies lower than or equal to 7 Hz resulted in the induction of LTD of both PSA and EPSP slope measures, with a shift to LTP occurring approximately between 11 and 30 Hz stimulation
Keywords :
brain; neurophysiology; anesthetized rat hippocampus; evoked field potentials; long-term depression; low-frequency stimulation; neuroplastic alterations; perforant path/dentate gyrus synapse; synapse modification; synaptic plasticity; Biomedical engineering; Biomedical measurements; Educational institutions; Electrodes; Frequency measurement; Hippocampus; Neuroplasticity; Pulse measurements; Rats; Signal analysis;
Conference_Titel :
Bioengineering Conference, 2000. Proceedings of the IEEE 26th Annual Northeast
Conference_Location :
Storrs, CT
Print_ISBN :
0-7803-6341-8
DOI :
10.1109/NEBC.2000.842398
