• DocumentCode
    2000484
  • Title

    A modified QT-clustering algorithm over Gene Expression data

  • Author

    Choudhury, Nirupam ; Sarmah, Rosy ; Sarma, Suranjon

  • Author_Institution
    Dept. of CS & Eng., Tezpur Univ., Tezpur, India
  • fYear
    2012
  • fDate
    15-17 March 2012
  • Firstpage
    542
  • Lastpage
    547
  • Abstract
    Clustering is often one of the first steps in Gene Expression Analysis. In this paper we propose a modified-QT clustering algorithm for gene expression datasets that uses a modified Pearson´s correlation measure to identify the clusters in gene expression data. Experimental results show the efficiency of the proposed method over several real-life datasets. The proposed method has been found to be better than other comparable algorithms in terms of z-score and p-value measures of cluster quality.
  • Keywords
    biology computing; genetics; pattern clustering; statistical analysis; cluster quality; gene expression datasets; modified Pearson´s correlation measure; modified QT clustering algorithm; p-value measure; quality threshold clustering; z-score; Biological cells; Clustering algorithms; Correlation; DNA; Gene expression; Heuristic algorithms; Software algorithms; Clustering; Gene expression data; Microarray; Pearson´s correlation coefficient; p-value; z-score;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Recent Advances in Information Technology (RAIT), 2012 1st International Conference on
  • Conference_Location
    Dhanbad
  • Print_ISBN
    978-1-4577-0694-3
  • Type

    conf

  • DOI
    10.1109/RAIT.2012.6194618
  • Filename
    6194618