DocumentCode
2009005
Title
Direct bio-mechanical sensing of enzymatic reaction On DNA by silicon nanotweezers
Author
Kumemura, M. ; Collard, D. ; Yoshizawa, S. ; Fourmy, D. ; Lafitte, N. ; Jalabert, L. ; Takeuchi, S. ; Fujii, T. ; Fujita, H.
Author_Institution
LIMMS-IIS, Univ. of Tokyo, Tokyo, Japan
fYear
2010
fDate
24-28 Jan. 2010
Firstpage
915
Lastpage
918
Abstract
This paper demonstrates the real-time sensing of enzymatic reactions on a DNA bundle trapped by silicon nanotweezers. The digestion of DNA in protein solution (Hind III) is monitored by tracking the change in frequency response of the immersed tweezers. This new direct biomechanical detection clears the way for systematic bio tests at the molecular level by an integrated MEMS device.
Keywords
bioMEMS; biochemistry; biomechanics; biosensors; enzymes; molecular biophysics; nanobiotechnology; silicon; DNA bundle; bio-mechanical sensing; biomechanical detection; enzymatic reaction; immersed tweezers; integrated MEMS device; molecular level; protein solution; silicon nanotweezers; systematic bio tests; Arm; Atomic force microscopy; Biochemistry; DNA; Frequency response; Micromechanical devices; Molecular biophysics; Nanobioscience; Probes; Silicon;
fLanguage
English
Publisher
ieee
Conference_Titel
Micro Electro Mechanical Systems (MEMS), 2010 IEEE 23rd International Conference on
Conference_Location
Wanchai, Hong Kong
ISSN
1084-6999
Print_ISBN
978-1-4244-5761-8
Electronic_ISBN
1084-6999
Type
conf
DOI
10.1109/MEMSYS.2010.5442356
Filename
5442356
Link To Document