Intrinsic precision limit in steady-state and time-domain fluorescence diffuse optical imaging

Author

Boffety, M. ; Allain, M. ; Sentenac, A. ; Massonneau, M. ; Carminati, R.

fYear

2011

fDate

22-26 May 2011

Firstpage

1

Lastpage

1

Abstract

In this communication, the intrinsic precision in the localization of a fluorescent source in a turbid medium is analyzed for various fluorescence diffuse optical tomography (fDOT) setups in reflection geometry via a rigorous statistical methodology, the Cramer-Rao bound. Firstly, a spatially and temporally resolved imaging technique (TD) is considered and the strong impact of the fluorescence life-time is revealed. Then, these performances are compared with other standard setups, namely a spatially resolved in a continuous wave setup (CW) and a single detector in a time resolved setup (ITD).

Keywords

estimation theory; fluorescence; optical tomography; time resolved spectra; time-domain analysis; Cramer-Rao bound; continuous wave setup; diffuse optical imaging; fluorescence diffuse optical tomography; intrinsic precision limit; reflection geometry; single detector; steady-state fluorescence; time resolved setup; time-domain fluorescence; turbid medium; Fluorescence;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC), 2011 Conference on and 12th European Quantum Electronics Conference

Conference_Location

Munich

ISSN

Pending

Print_ISBN

978-1-4577-0533-5

Electronic_ISBN

Pending

Type

conf

DOI

10.1109/CLEOE.2011.5943248

Filename

5943248