NMR investigation of the same charged gelling biosystems for drug capsulation

It is proposed a series of new NMR relaxometry, diffusometry, spectroscopy techniques for the development of drug capsulation technology. On the basis of this NMR study a new capsulation system, the same charged gelling biosystem, was proposed. The nanostructure properties of the gelling bio-system including the phase diagram, nanopore and aggregate radii, drug release rate, system stability were measured using a new diffusion-specific probe, the same charged surfactant micelles, and theoretical approach of diffusion problem with complex variable representation. Drug release rate from the bio-capsule was determined using new NMR localization method without the application of the magnetic field gradients. The stability of the capsulating nanobiosystems was controlled by NMR relaxometry of water protons and parallely by the DSC and CD methods. The results show high sensitivity of the NMR methods to study homogeneous hydrogels with low volume fraction, an agreement with the X-ray diffraction data and promising perspectives for the use of the same charged gelling biosystems as high drug capacity, rate-controlled, bioadhesive media in pharmacology.