Title :
A Novel Micro-spraying System for Preparing Polymer-coated Intravascular Stent
Author :
Luo, Lailong ; Wang, Guixue ; Yin, Tieying ; Shen, Yang ; Hou, Yanbin ; Li, Yan ; Jiang, Tao
Author_Institution :
Chongqing Univ., Chongqing
Abstract :
In order to prepare the polymer coating effectively and simply on the stent, which avails producing the drug eluting stent (DES), a novel micro-spraying system was introduced in this paper. Based on the theory of ultrasonic atomization, the spray system was designed and established which was composed of four primary modules. The optimized spray parameters were also determined through orthogonal experiment for preparing coating by the system. The fluorescence stain and image analysis were used to make the morphologies of coating more apparent. Our experimental results reveal that the spray system designed in this paper is suitable for preparing polymer coating, which will facilitate the development of DES.
Keywords :
biomedical materials; drug delivery systems; fluorescence; polymer films; sprays; drug eluting stent; fluorescence stain image analysis; microspraying system; polymer coating; polymer-coated intravascular stent; ultrasonic atomization; Circuits; Coatings; Drugs; Fluorescence; Frequency; Image analysis; Polymer films; Spraying; Surface morphology; Switches; DES; fluorescence stain; image analysis; polymer coating; ultrasonic atomization;
Conference_Titel :
Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-1077-4
Electronic_ISBN :
978-1-4244-1078-1
DOI :
10.1109/ICCME.2007.4382089