Tissue enhanced optical imaging and monitoring of drug delivery

Tissue optical clearing technology in application to enhanced optical imaging and monitoring of drug delivery in the framework of receiving of more precise and valuable information from reflectance spectroscopy, polarization measurements, Raman spectroscopy, confocal microscopy, and optical coherence tomography (OCT), as well as from nonlinear spectroscopies, such as two-photon fluorescence, second harmonic generation (SHG) and terahertz spectroscopy. In vitro, ex vivo, and in vivo spectroscopic, polarization, and OCT studies of human tissues will be presented. Optical clearing agents and delivery techniques, as well as tissue enhanced permeation, will be discussed. Some important applications of optical immersion technique in dermatology, ophthalmology, gastroenterology, and some other medical fields will be demonstrated.